This agreed with Eggers et al. [23] who found that GDF-15 exhibited the strongest incremental value to cardiovascular risk indicators, both in terms of prognostic discrimination and reclassification of cardiovascular risks (95% CI, 0.71 (0.67–0.76)) in comparison to NT-proBNP (P value < 0.001 and 0.040, respectively) in COVID-19 pathophysiology [24]. The gene discussed is NPPB; the disease is COVID-19.