According to World Health Organization cervical pathological classification in 2014, CIN2 can be divided into two categories based on histological Cyclin-Dependent Kinase Inhibitor 2A (P16) results: low squamous intraepithelial lesions(LSIL) including CIN1 and P16-negative CIN2, and high squamous intraepithelial lesions(HSIL) including CIN3 and P16-positive CIN2 [5]. The gene discussed is CDKN2A; the disease is squamous cell intraepithelial neoplasia.