FIDELITY was a prespecified pooled analysis of efficacy and safety data from FIDELIO and FIGARO and allowed for evaluation across the range of CKD severity [96] (N = 13,026; broad spectrum of CKD and T2DM; all patients were treated with an optimized dose of angiotensin-converting enzyme inhibitor or ARB) [100]. Here, ACE is linked to chronic kidney disease.