An Alzheimer Disease Neuroimaging Initiative (ADNI) study investigating CETP polymorphisms rs5882 (I405V) and (rs1800775) C-629A in 188 controls and 318 AD or mild cognitive impairment (MCI) patients reported that, in APOE4 carriers, the CETP V and A alleles, both of which decrease CETP activity and increase HDL, were associated with greater cortical thickness at baseline and less atrophy over 12 months in the medial temporal lobe. The gene discussed is CETP; the disease is early-onset autosomal dominant Alzheimer disease.