CETP and Cognitive impairment: An Alzheimer Disease Neuroimaging Initiative (ADNI) study investigating CETP polymorphisms rs5882 (I405V) and (rs1800775) C-629A in 188 controls and 318 AD or mild cognitive impairment (MCI) patients reported that, in APOE4 carriers, the CETP V and A alleles, both of which decrease CETP activity and increase HDL, were associated with greater cortical thickness at baseline and less atrophy over 12 months in the medial temporal lobe.