However, in recent years, animal models demonstrated that pathogenic variants of WWOX are associated with two major autosomal recessive neurological disorders, a relatively mild spinocerebellar ataxia 12 (SCAR12; OMIM:614322) and a more severe early infantile WWOX-related epileptic encephalopathy (WOREE syndrome). This evidence concerns the gene WWOX and developmental and epileptic encephalopathy, 28.