Univariate and multivariate analyses identified factors associated with JDM-ILD, including higher ESR (OR, 3.58; 95% CI 1.21–11.19, P = 0.023), higher IL-10 levels (OR, 1.19; 95% CI, 1.02–1.41, P = 0.038), positivity for MDA-5 antibodies (OR, 5.47; 95% CI, 1.11–33.43, P = 0.045). This evidence concerns the gene IL10 and interstitial lung disease.