ROC curves were generated to assess the capability of these genes to distinguish HF from normal, and the AUCs of CD163 and RNASE2 were 0.75 (95% CI 0.59–0.92) and 0.74 (95% CI 0.59–0.90), respectively, indicating that CD163 and RNASE2 may serve as novel biomarkers of HF (Fig. 8C, D). The gene discussed is RNASE2; the disease is hydrops fetalis.