Based on macrophage-related genes in the black and yellow module, MDRGs, and DEGs between HF and normal samples, we found that the intersection of these results yielded 4 hub genes (VSIG4, CD163, RNASE2, LYVE1) (Fig. 7C), which were significantly downregulated in HF than in normal samples. The gene discussed is RNASE2; the disease is hydrops fetalis.