EGFR and neoplasm: In addition, it has been shown that low expression of miR-31-3p could be a consequence of the regulation of pre-mir-31 maturation by an EGFR-activated pathway, driving tumor sensitivity to anti-EGFR therapy [58].Our meta-analysis showed that low miR-31-3p expression predicted PFS (interaction test P = 0.01) and OS benefit (interaction test P = 0.04) from anti-EGFR mAb treatment.