ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; CCB, calcium channel blocker; DBP, diastolic blood pressure; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; hs-CRP, high-sensitivity C-reactive protein; HTN, hypertension; LVEF, left ventricular ejection fraction; NT-pro BNP, N-terminal pro-brain natriuretic peptide; SBP, systolic blood pressure; TNF-α, tumor necrosis factor-α. The gene discussed is NPPB; the disease is diabetes mellitus.