RUNX2 and craniosynostosis: Though not identified in the current GWAS, several other genes (ERF110, SIX2111, SMAD6111, SMURF1111, MSX2112, ALX4112, TWIST1113, TCF12113, EPHA4114, and FREM1115) implicated in syndromic and non-syndromic forms of craniosynostosis affect ossification of the suture mesenchyme through modulation of BMP, FGF, or HH signaling and/or attenuation of RUNX2 expression, highlighting the shared molecular pathways of craniosynostosis and normal cranial vault development.