SIK3 and cancer: We surveyed individual colony genomes of all patients for the presence of potential cancer-associated mutations and identified 12 possible pathogenic mutations in RUNX1, TP53, CDKN2A, DNMT3A, SIK3, EZH2 (three independent mutations), TET2, CBLC, MGA and PPM1D (Fig. 4a,b and Supplementary Table 2).