We surveyed individual colony genomes of all patients for the presence of potential cancer-associated mutations and identified 12 possible pathogenic mutations in RUNX1, TP53, CDKN2A, DNMT3A, SIK3, EZH2 (three independent mutations), TET2, CBLC, MGA and PPM1D (Fig. 4a,b and Supplementary Table 2). This evidence concerns the gene PPM1D and cancer.