Published BCLM cohorts show an enrichment for invasive lobular cancer (ILC)7–9, the most common ‘special’ subtype of breast cancer10,11 which is characterised histologically by discohesive tumour cells arranged in single files or as individual cells, driven predominantly by mutational inactivation of CDH1 (E-cadherin)12,13. Here, CDH1 is linked to neoplasm.