BDNF and Anxiety: When we investigated the importance of the BDNF-TrkB axis in the ability of MSCs to improve depressive and anxiety-like behaviors, we found that BDNF-knockdown MSCs could not rescue the CRS-induced decreases in distance traveled and time spent in the center field of the OFT, time spent in and entry numbers to open arms in the EPM, and the increase in immobile time in the TST (Supplementary Fig. 10).