When the top NMF genes were assigned to one of 19 protein complex groups23, epifactors belonging to histone acetyltransferase (HAT) complexes were significantly enriched (P < 0.05) among the top NMF genes for seven cancer types (LIHC, GBM, UCEC, BRCA, LUAD, KIRP, and PAAD). This evidence concerns the gene TMPRSS11D and cancer.