Out of the 21 genes that were a top NMF gene in at least two pediatric cancer types (Fig. 6d), seven genes (ASF1B, AURKB, SMARCD3, TONSL, UBE2T, ZBTB7C, and ZNHIT1) were shared with the 27 most frequent top NMF genes in adult cancers (Fig. 1f). Here, ZNHIT1 is linked to cancer.