Out of the 21 genes that were a top NMF gene in at least two pediatric cancer types (Fig. 6d), seven genes (ASF1B, AURKB, SMARCD3, TONSL, UBE2T, ZBTB7C, and ZNHIT1) were shared with the 27 most frequent top NMF genes in adult cancers (Fig. 1f). This evidence concerns the gene ZBTB7C and cancer.