In fact, we found p-eIF2α(S51) and one of the major ISR effectors, CHOP, to be consistently upregulated by DOXY in nearly all tested cell lines (neuroblastoma: 11/11; other nerve tissue tumors: 6/7; normal fibroblasts: 1/1) regardless their vulnerability to DOXY-induced cell death. The gene discussed is DDIT3; the disease is neuroblastoma.