In this study, we found that the mitoribosome inhibition-induced ISR leads to degradation of short-lived MYC proteins and that the upregulation of their T58-phosphorylated forms, tagging MYC proteins for rapid proteasome degradation [58, 60, 75, 76], sensitizes MYC-driven neuroblastoma to inhibition of mitoribosomes. Here, MYC is linked to neuroblastoma.