Conversely, cell types lacking aberrantly upregulated expression and phosphorylation of MYC proteins, such as normal fibroblasts (Figs. 3g, 7e), did not undergo cell death after mitochondrial ISR activation, which suggests a promising opportunity for developing mitoribosome targeting therapies that would be efficient against MYC-driven neuroblastomas while sparing healthy tissues. Here, MYC is linked to neuroblastoma.