We considered that the antioxidant activity of the flavones may be responsible for their protective effect, as FSHD pathology is associated with oxidative stress [46, 50, 85] and antioxidants have been shown to inhibit DUX4-induced toxicity in DUX4-expressing C2C12 cells [32, 86]. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.