Next, we detected the expression of VIMENTIN, E-CADHERIN, and SLUG in orthotopic lesion sections of mouse CRC spleen-liver metastasis models by IHC, which showed that E-CADHERIN levels were increased and that VIMENTIN and SLUG levels were significantly decreased in the circSKA3-knockdown group (Fig. 5L). Here, VIM is linked to colorectal carcinoma.