For example, CiRS-7 and circCER regulate EMT via ceRNA [25, 26], circUSUN2 promotes CRC liver metastasis by stabilizing high-mobility group A2 [27], and circSPARC regulates the JAK2-STAT3 signaling pathway by binding to miR-485-3p and FUS to promote CRC metastasis [28]. Here, JAK2 is linked to colorectal carcinoma.