PHLPP2 and hepatocellular carcinoma: To date, many specific circRNAs have been identified in multiple types of tumors that regulate tumorigenesis and progression; for example, circVAMP3 accelerates the formation of stress granules and suppresses the translation of the proto-oncogene c-myc in hepatocellular carcinoma (HCC) [3], and circANAPC7 can inhibit pancreatic cancer progression via the PHLPP2-AKT-TGF-β signaling axis [4].