Given the existence of tumor control mechanisms beyond the radiation site, we further explored whether silencing PRMT3 in combination with radiotherapy had the potential to produce a greater abscopal effect.[28] In the bilateral tumor model, radiation significantly slowed the growth of tumors on the treated side compared to the untreated control side, and there was a slight reduction in tumor volume on the nontreated side, with elevated levels of ferroptosis on both sides. This evidence concerns the gene PRMT3 and neoplasm.