SMAD3 and esophageal squamous cell carcinoma: HSPA8 has been reported to play an essential role in metastasis in several types of cancers.[33] For instance, HSPA8 promoted breast cancer metastasis by degrading Dicer in breast cancer cells.[34] In addition, DJ‐1 bound to HSPA8 to promote Smad3 phosphorylation and nuclear aggregation in a protein‐interaction–dependent manner, thereby activating the TGF‐β pathway and esophageal squamous cell carcinoma metastasis.[35] However, the role and underlying mechanisms of HSPA8‐mediated CRC metastasis are largely unknown.