The results showed that HSPA8 knockdown suppressed the expression of mesenchymal markers (ZEB1, Vimentin, and Slug), upregulated the epithelial marker (E‐cadherin and Claudin‐1) and consistently decreased migratory and invasive ability in CRC cells, while overexpression of HSPA8 resulted in the opposite phenotype (Figure 2C–L and Figure S4B–H, Supporting Information). This evidence concerns the gene HSPA8 and colorectal carcinoma.