Due to its important role in tumorigenesis and tumor progression, CAV1 has attracted extensive attention in recent years.[39] Loss of CAV1 is widely reported in the progression of various tumors, including CRC, and is closely related to tumor metastasis and drug resistance.[40] Recent studies have also reported a potential link between CAV1, BRAF V600E mutation and the downstream signaling pathways of BRAF.[41]. This evidence concerns the gene BRAF and colorectal carcinoma.