To investigate the function of HSPA8 in BRAF V600E CRC, endogenous HSPA8 was stably knocked down by short hairpin RNA (shRNA) in RKO (BRAF V600E cell line) and SW480 (BRAF wild‐type cell line) cells (Figure2A and Figure S4A, Supporting Information). Here, HSPA8 is linked to colorectal carcinoma.