When compared with the control group, the protein levels of the proinflammatory mediators (TNF-α, IL-1β and IL-6) and the anti-inflammatory factor IL-10 examined were significantly elevated in the paw tissues of model mice at both 2 months and 4 months after the initial induction of gouty arthritis (figure 6A–D), while no significant differences were viewed in TNF-α, IL-1β, IL-6 and IL-10 protein levels between model mice at 2 months and model mice 4 months after initial induction of gouty arthritis. The gene discussed is TNF; the disease is gout.