Third, studies in animal models, including in a mouse model of type 1 diabetes, have shown that silencing of APOC3 prevents the formation of both early and advanced lesions of atherosclerosis characterized by necrotic core expansion (10, 11, 12), while mice transgenic for human APOC3 have 2- to 3-fold larger atherosclerotic lesions than controls (13). The gene discussed is APOC3; the disease is atherosclerosis.