For example, in the FinnDiane study on subjects with type 1 diabetes, systemic inflammation characterized by elevated levels of hsCRP had only minor effects on the association between APOC3 and CVD events (18), and an APOC3 loss-of-function variant was associated with slightly increased hsCRP levels in the UK Biobank, rather than reduced levels, as one would expect if APOC3 increased hsCRP levels (29). The gene discussed is APOC3; the disease is type 1 diabetes mellitus.