Moreover, in a recent mouse study, deletion of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in hematopoietic chimeras with diabetes resulted in reduced plasma levels of APOC3 without a significant drop in plasma triglycerides (66) and human studies show an interaction between plasma APOC3 levels and an NLRP3 variant that causes increased NLRP3 activity (67). This evidence concerns the gene APOC3 and diabetes mellitus.