NLRP3 and diabetes mellitus: Moreover, in a recent mouse study, deletion of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in hematopoietic chimeras with diabetes resulted in reduced plasma levels of APOC3 without a significant drop in plasma triglycerides (66) and human studies show an interaction between plasma APOC3 levels and an NLRP3 variant that causes increased NLRP3 activity (67).