APOC3 and coronary artery disorder: For example, one study showed a positive association between both total APOC3 and APOC3 carried by APOB-lipoproteins with coronary heart disease in subjects with type 2 diabetes and median triglycerides in the normal range (19), whereas in another study, APOC3 levels associated negatively with CVD, despite a positive correlation with triglycerides (20).