MAPT and supranuclear palsy, progressive, 1: Indeed, autonomic and sensory disturbances, with electrophysiological and pathological features have been reported in PSP.8-10 Histopathologically, PSP patients displayed a length-dependent loss of sensory and autonomic nerve fibres in the skin biopsy samples.9 Interestingly, the P301L mutant tau transgenic animal model exhibits motor deficits with severe peripheral nerve involvement, such as axonal spheroids in the anterior spinal roots, axonal degeneration in peripheral nerves and neurogenic skeletal muscle atrophy,48 supporting the notion of peripheral involvement in tau-related diseases.