However, the previous study examining TDP-43 pathology in PSP documented that the presence or absence of spinal cord TDP-43 pathology was not significantly associated with LATE stage and that extra-limbic TDP-43 pathology differs from the spreading manner of LATE.20,30 Altogether we concluded that no association between PNS-tau and TDP-43 pathology can be confirmed in our study. The gene discussed is TARDBP; the disease is supranuclear palsy, progressive, 1.