MAPT and supranuclear palsy, progressive, 1: However, a recent study suggests that tauopathies can be distinguished based on the structure of tau filaments.3 We can speculate that, similarly to CNS-tau, differences in the conformational properties of misfolded tau and predominance of tau isoforms, as seen also in PSP and CBD,3 may be related to the susceptibility of tau lesions to peripheral nerves, namely, the pathological tau in PSP may be more prone to invade PNS.