p53-armed OBP-702 induced apoptosis in BRAF-mutant CRC cells, whereas non-armed OBP-301 or p53-expressing Ad-p53 did not induce apoptosis, suggesting that p53-activating oncolytic virotherapy would be effective for treating BRAF-mutant CRC via apoptosis induction. Here, TP53 is linked to colorectal carcinoma.