To explore the underlying mechanism of differing sensitivity to OBP-301 and OBP-702 in BRAF-mutant CRC cells, we investigated whether OBP-301 and OBP-702 suppress the EGFR-MEK-ERK and AKT-mTOR signaling pathways in BRAF-mutant CRC cells. Here, AKT1 is linked to colorectal carcinoma.