PRDX4 and glioblastoma: Of note, hydroxyl is produced from H2O2 when enzymes responsible for converting H2O2 to water cannot keep up with H2O2 levels, suggesting that the upregulation of these enzymes seen in invasive GBM43 cells (Supplemental Table 7), such as peroxiredoxin 3 (PRDX3) (log2FC = 0.6, P = 0.001) and 4 (PRDX4) (log2FC = 0.5, P = 0.003) and GPX8 (log2FC = 0.8, P = 0.0002), is insufficient to address the H2O2 in invading GBM cells.