ACADL mediates fatty acid oxidation, which protects against ferroptosis (29), a finding consistent with our lipidomic findings (Figure 2E), and GGT5 hydrolyzes glutathione before it is recycled to cysteine, a potential response to the increased flux through the transsulfuration pathway suggested by the increased cystathionine identified in our metabolomic analysis of invasive GBM cells (Figure 1C). This evidence concerns the gene ACADL and glioblastoma.