Specifically, integration of our multiomic findings (Figure 5E) suggested increased flux through the transsulfuration pathway in invasive GBM cells based on upregulated glutathione turnover enzymes, with CTH a rate-limiting targetable transsulfuration step in invasive GBM cells based on the accumulation of cystathionine in these cells without changes in transsulfuration enzyme gene expression. The gene discussed is CTH; the disease is glioblastoma.