However, the nonmetastatic melanoma cell line WM793, with endogenously high WNT5B levels, did not show any significant change in the WNT5B mRNA levels upon siNOTCH3 or DAPT treatment, suggesting regulatory pathways other than Notch3 for the sustained, high WNT5B expression in this cell line (Figure 5, A and B, and Supplemental Figure 6, A and B). This evidence concerns the gene WNT5B and melanoma.