CD8A and neoplasm: Furthermore, melanoma-secreted extracellular vesicles educate the tumor-draining lymph nodes to enhance lymphatic metastasis in many ways, for instance through neural growth factor receptor–dependent signaling (6); by shuttling tumor antigens to lymph node LECs for cross-presentation on MHC-I, resulting in apoptosis induction in antigen-specific CD8+ T cells (7); or by compromising the maturation process of the lymph node–residing dendritic cells (8).