WNT5B and familial pancreatic carcinoma: For instance, WNT5B promotes proliferation and invasion of certain breast cancer and oral squamous cell carcinoma cell lines (15–17), in genomic analyses it associates with the most aggressive pancreatic cancer subtype (18), and pancreatic cancer cells that have undergone mesenchymal transition have been shown to promote the metastatic potential of the neighboring epithelial cells (19).