PROX1 and Sepsis: Additionally, the percentage area coverage and the relative intensity of pulmonary lymphatic vessels (Prox1-tdTomato+VEGFR-3+/Prox1-tdTomato+CD31+/Prox1+) were overall decreased in LPS/CLP-induced sepsis mice (Figure 3, B and C; Supplemental Figure 3, B and D; Supplemental Figure 4, A and B; and Supplemental Figure 15), especially at 24 hours and 48 hours (Figure 3, B and C).