Moreover, VEGF-C156S posttreatment increased the percentage area and the relative fluorescence intensities of pulmonary/LN lymphatic vessels (Prox1-tdTomato+VEGFR-3+/Prox1-tdTomato+CD31+) (Figure 4, B–D, and Supplemental Figure 8, B and C) and endothelial integrity (Supplemental Figure 19) in LPS/CLP-induced sepsis mice. This evidence concerns the gene PROX1 and Sepsis.