Then, we found that VEGF-C156S posttreatment accelerated the drainage of ICG/FITC-dextran from the lung into the pLNs in LPS/CLP-induced sepsis mice (Figure 4, F–K; Supplemental Figure 8, F–K; and Supplemental Figure 18), indicating that VEGF-C156S–induced lymphatics rejuvenation could ameliorate the pulmonary lymphatic drainage during sepsis. This evidence concerns the gene VEGFA and Sepsis.