CFAP418 and Bardet-Biedl syndrome: Considering its high evolutionary conservation, expression across many developing and mature tissues (9, 12), involvement in melanosome transport in nonciliated zebrafish melanophores (12), and BBS phenotypes in multiple organ systems (9, 12, 13), the role of CFAP418 in lipid binding, homeostasis, and membrane remodeling is likely conserved and important for cell survival and function across tissues and species.