Two small molecular IGF1R tyrosine kinase inhibitors — BMS-754807 (18) and picropodophyllin (PPP) (19) — at 1 μM thwarted BPH-1 spheroid formation and BPH organoid formation in Matrigel (P < 0.001; 2-sided Student’s t test) (Figure 7, A–C, E–H, and J, and Supplemental Figure 4). The gene discussed is IGF1R; the disease is benign prostatic hyperplasia.