Treatment of Epm2b-/- mice with FGD reduced the number of infiltrated T-cells in comparison to untreated mice (CD3 + , 2.3 ± 2.4, P < 0.05; CD4 + , 0.3 ± 0.5, P < 0.01; CD8 + , 1.5 ± 1.6, P < 0.05) (Fig. 7A–D). This evidence concerns the gene CD8A and Aarskog-Scott syndrome, X-linked.