MAPT and Alzheimer disease: However, the disease-related p-tau 231 and p-tau 396 positive neurons in the cortex and hippocampus of THz-treated AD mice were considerably less than those of AD control mice (29% and 19% reduction of p-tau 231 and p-tau 396 positive neurons in the cortex, both P <0.0001; 45% and 20% reduction of p-tau231 and p-tau 396 positive neurons in the hippocampus, both P <0.0001; Fig. 3A-F).