The top ten KEGG pathways are mainly associated with a HIF-1 signaling pathway, glycolysis/gluconeogenesis, central carbon metabolism in cancer, thiamine metabolism, selenocompund metabolism, glycosaminoglycan degradation, one carbon pool by folate, histidine metabolism, renin-angiotensin system, and beta-alanine metabolism (Fig. 9B). Here, REN is linked to cancer.