A significantly higher 99mTc-PSMA-I&S uptake (SUVARG) was observed in areas with prostate cancer compared with benign prostate tissue (15.6 ± 11.7 in n = 1177 vs. 5.0 ± 5.4 in n = 3483 grids; p < 0.001, Fig. 5A). This evidence concerns the gene FOLH1 and Familial prostate cancer.