DUSP1 and juvenile Huntington disease: Downregulation in DUSP1 transcripts was also described in the cortex and striatum of mice models of Huntington’s disease (HD) and postmortem samples of HD patients (Luthi-Carter et al. 2002; Taylor et al. 2013), in addition to decrease in DUSP1 activity in PD patients (Collins et al. 2013).