Some of the most widely marketed PDE inhibitors fall under the diverse category of cardiovascular drugs, primarily including cardiotonics for congestive HF, vasodilatory agents for hypertension, pulmonary arterial hypertension, intermittent claudication, and cerebrovascular disorders, and antiaggregates for thrombosis-related events (557). The gene discussed is ALDH7A1; the disease is hypertensive disorder.