KLK3 and Familial prostate cancer: The recommended follow-up protocol after focal treatment of prostate cancer should span a minimum of 2 years, including PSA measurements every 3 months, mpMRI every 6 months, and annual biopsies.16 Changes in PSA values are generally influenced by prostate size and the presence of other diseases, but on average, there is an approximate 70% decrease in PSA levels following treatment.