The European Society for Medical Oncology recommends a combination of clinical assessments, regular measurements of carcinoembryonic antigen levels, computed tomography (CT), and a colonoscopy with higher frequencies for the first 3 years after curative surgery and for a total duration of 5 years in patients with nonmetastatic CRC.14,43 However, substantial variation has been found between national surveillance guidelines,44 and a Cochrane Review45 found no benefit of intensified surveillance on overall survival. The gene discussed is CEACAM5; the disease is colorectal carcinoma.