MKI67 and neoplasm: In the univariate analysis, the risk of PFD for the entire cohort was significantly affected by age >46 years (P=0.02), female gender (P=0.03), pathological stages II (P=0.04) and IIIA (P<0.001), tumor size >2.0 cm (P=0.009), number of positive lymph nodes ≥1 (P<0.01), NG1 (P=0.03), and NG2 (P=0.04), whereas the Ki-67 PI was borderline significant (Table 5).