It has been reported that in myocardial fibrosis, liver fibrosis, glaucoma, and other diseases, the TGF-β signaling pathway is also involved in angiogenesis, ECM remodeling, pathological scar healing (Ilieș et al., 2021; Lee and Massagué, 2022; Ferrão et al., 2018; Penn et al., 2012). Here, TGFB1 is linked to glaucoma.