Our findings showed that the HER3-HBP-DOX nanoparticles providedmodest survival benefit over saline, free DOX, and untargeted HBP-DOX.The mice treated with HER3-HBP-DOX showed reduced tumor growth ratesand smaller tumor volumes, indicating the inhibitory effect HER3-HBP-DOXhas against BM tumor. Here, ERBB3 is linked to neoplasm.