The innate immune cells modulate osteoporosis by producing several proinflammatory mediators (such as interleukin‐1‐beta, IL‐1β; interleukine‐6, IL‐6; tumor necrosis factor‐α, TNF‐α, and toll‐like receptor 4, TLR4) and affecting the receptor activator of nuclear factor‐κB (RANK)/ligand for a RANK receptor (RANKL)/osteoprotegerin (OPG) axis (Breedveld et al., 2021). The gene discussed is TNFRSF11B; the disease is osteoporosis.