We found that serum paraoxonase/arylesterase 1 (PON1) was positively associated with osteoporosis in East Asian (Figure S7a, Table S8), while cholinesterase (BCHE) was significantly associated with LS‐BMD, and apolipoprotein L1 (APOL1) was significantly associated with FN‐BMD and heel eBMD in European population (Figure S7b–d, Table S9). This evidence concerns the gene BCHE and osteoporosis.