Recently it has been reported that the adoptive NRTs transferring induced by cancer vaccines containing mutant peptides effectively repressed tumor cell growth in CRC‐bearing mice models.[19] Moreover, the coexpression of CD39 and CD103 is a hallmark of neoantigen‐specific CD8+ T cells in patients with MMR‐proficient CRC and low mutation burden. This evidence concerns the gene CD8A and colorectal carcinoma.