In the mentioned patients, NRTs (CD8+CD39+CD103+T cell subset) could be detected in the tumor milieu, where the TGF‐β level is significantly elevated to suppress anti‐tumor immune responses, and this problem can be partially alleviated with combination therapies.[96] Another study disclosed the presence of NRTs in several types of MMR‐p‐associated metastatic gastrointestinal malignancies, such as CRC. This evidence concerns the gene CD8A and colorectal carcinoma.