Additionally, this approach improved the effectiveness of immune checkpoint inhibitors.[99] Another investigation on 196 screened peptides reported that stimulation of enriched neoantigen‐specific TILs, specially HDHD3, could increase the expression of CD137 (4‐1BB), a member of the tumor necrosis factor (TNF) receptor superfamily T cell costimulatory receptor, CD134, (OX40), TNFα, IFNγ, and granzyme B than in non‐reactive TILs.[100] Therefore, screening and identifying specific neoantigens can be effective in more targeted treatment of CRC and improving the NRT‐mediated antitumor responses. Here, TNF is linked to colorectal carcinoma.