Galectin-9 expression was determined in leukemic cells in AML and chronic lymphoblastic leukemia (11, 25), also, TIM-3 overexpression in BM and PBMCs in ALL patients including B- and T-ALL has been previously reported (26); while the prognostic role of Galectin-9 and TIM-3 in B-ALL has not been investigated. The gene discussed is HAVCR2; the disease is acute lymphoblastic leukemia.