In conclusion, this study successfully demonstrated that 315‐g quinoa seed/1000 g of chow diet supplementation to cafeteria diet reduced energy intake, differentiated macronutrient intake, regulated glucose homeostasis, attenuated microvesicular steatosis, hepatocyte degeneration, increased IRS‐1 and AMPK in the liver. The gene discussed is IRS1; the disease is steatosis.