Due to the high levels of inflammation and oxidative stress in CABG patients and the exacerbating effect of depression on the levels of these factors, we investigated the effect of hesperidin on depressed CABG patients, but studies on the anti‐inflammatory and oxidative effects of hesperidin are limited, especially in humans, and further studies are needed to investigate the effect of hesperidin on OX‐LDL and P‐selectin in humans. The gene discussed is SELP; the disease is depressive symptom measurement.