POLE and anemia: codes for the riboendonuclease dicer (DICER1), fibroblast growth factor receptor 3 (FGFR3), Janus kinase 3 (JAK3), suppressor of fused homology (SUFO), family with sequence similarity 46, member c (FAM46C), Fanconi anemia complementation group G (FANCG), phospholipase C gamma 2 (PLCG2), DNA polymerase epsilon catalytic subunit A (POLE), epithelial cell adhesion molecule (EPCAM), mutY DNA glycosylase (MUTYH), androgen receptor (AR), APC and MET to be responsible for small cell variant of chRCC.