codes for the riboendonuclease dicer (DICER1), fibroblast growth factor receptor 3 (FGFR3), Janus kinase 3 (JAK3), suppressor of fused homology (SUFO), family with sequence similarity 46, member c (FAM46C), Fanconi anemia complementation group G (FANCG), phospholipase C gamma 2 (PLCG2), DNA polymerase epsilon catalytic subunit A (POLE), epithelial cell adhesion molecule (EPCAM), mutY DNA glycosylase (MUTYH), androgen receptor (AR), APC and MET to be responsible for small cell variant of chRCC. This evidence concerns the gene PLCG2 and anemia.