An investigation identified promoter methylation of basonuclin 1 (BNC1), signal peptide, CUB domain and EGF like domain containing 3 (SCUBE3), GATA binding protein 5 (GATA5), secreted frizzled-related protein 1 (SFRP1), gremilin 1 (GREM1), Ras association domain family 1 isoform A (RASSF1A), protocadherin 17 (PCDH17), laudinin 1 (LAD1) and neurofilament heavy polypeptide (NEFH) coding genes as potential diagnostic and prognostic methylation biomarkers for RCC [28]. The gene discussed is GREM1; the disease is renal cell carcinoma.