For example, melatonin increases mitophagy and PTEN-associated kinase 1 (PINK1)/parkin to suppress CD8+ T cell chemoattraction in “immune-mediated” conditions, such as Parkinson’s disease [2, 89], but suppresses mitophagy in cancer cells [90], whilst also derepressing CD8+ T cells [60]. The gene discussed is CD8A; the disease is Parkinson disease.