Alterations in the NAS/melatonin ratio, AhR levels and ligands, and hypothalamic/pituitary hormones, coupled with GR translocation to the nucleus, versus mitochondria, and GR-induced TDO will have differential effects in different microenvironment cells thereby altering the homeostatic interactions in different microenvironments across the body. Here, NR3C1 is linked to tricho-dento-osseous syndrome.