It requires investigation whether the suppression of pineal and/or local melatonin’s capacity to keep the GR in a cytoplasmic complex with Hsp90 [44] contributes to enhanced Rb/GR/BAG-1 nuclear translocation in cancer pathogenesis, leading to TDO/kynurenine/AhR driven increases in the NAS/melatonin ratio in the precancerous microenvironment cells, thereby enhancing TrkB-driven proliferation, as an aspect of wider alterations in homeostatic, intercellular, metabolic interactions. Here, RB1 is linked to cancer.