Whether AhR activation, via CYP1B1 and CYP1A2, in NK cells and CD8+ T cells, increases the NAS/melatonin ratio and NAS release to activate TrkB on cancer stem-like cells, thereby not only increasing survival and proliferation but also further changing the metabolic interactions in the tumor microenvironment will be important to determine. Here, CYP1B1 is linked to neoplasm.