CD8A and neoplasm: As tumor kynurenine is released to activate the AhR on natural killer (NK) cells and CD8+ T cells to induce “exhaustion” [54], the circadian interactions of pineal melatonin, BAG-1, CAR, and the AhR will significantly impact intercellular interactions in the tumor microenvironment to favor tumor survival when pineal melatonin is suppressed [8, 55].