Furthermore, we have previously discussed about different phyto-compounds/natural polyphenols like curcumin, quercetin, genistein, glycyrrhizin, resveratrol, epigallocatechin gallate and garcinol, with anti-oxidant, anti-glycation and/or anti-inflammatory properties, simultaneously eliciting cancer cell death, potentially via inhibition of RAGE and/or its ligands [12]. The gene discussed is AGER; the disease is cancer.