Hence the AGEs-RAGE signalling in CAFs, one of the most vital components of TME, plays crucial interplay between the CAFs and cancer cells by instigating AGEs-RAGE-ROS-ERK 1/2-AKT-c-Fos signal conversion cascade, resulting in the expression and release of IL-8, which by paracrine signal driven chemokine receptor (CXCR1/2) engagement prompts malignant features in cancer cells. This evidence concerns the gene AGER and cancer.