Established the efficacy of FPS-ZM1 in blocking the AGEs-induced interaction between CAFs and breast cancer cells, by inhibiting RAGE; AGE-driven IL-8 rise in CAFs, promoting elicitation of invasive/malignant features in cancer cells, was inhibited via blockade of RAGE-ROS-ERK 1/2-AKT-c-Fos signal cascade. This evidence concerns the gene AKT1 and breast carcinoma.