Furthermore, papaverine-mimetic 3-styrylchromone derivative developed recently by Tanuma et al. [83] exhibited anti-inflammatory, anti-proliferative and anti-cancer effects via suppression of HMGB1-RAGE-ERK 1/2 signalling; anti-apoptotic effects via augmented pro-apoptotic Bax and caspase-3/7 expression in HCT116 colon cancer cells, both individually and in synergistic combination with DNA damaging agents. Here, HMGB1 is linked to colonic neoplasm.