Consequently, the generation of AGEs via glycolytic abundance link the metabolic shift of cancers to sustained inflammation via RAGE activation (AGEs-RAGE-NF-κB, AGEs-RAGE-HMGB1/S100, AGEs-RAGE-NOX-2, AGEs-RAGE-IL-8-CXCR1/2 and RAGE-IGF-S100A7) in cancers. The gene discussed is S100B; the disease is cancer.