HMGB1 and cancer: Enhanced glycolytic signature and exhaustive glucose uptake of cancer cells facilitate glycation reactions and the formation of AGEs (coupled with ROS generation), subsequently resulting in activation of RAGE and its other ligands—HMGB1 (redox-sensitive DAMP associated with inflammation and autophagy) and S100A4 (metastasis associated protein), with implications in cancer progression, metastasis and chemo-resistance.