Metabolic insurgence or re-programming of cancers (dysregulated cellular bio-energetics) is strong and sufficient enough as a stand-alone hallmark capable of generating all the other hallmarks of cancer namely, sustained proliferative signals, tumour suppression, apoptotic evasion, inflammation, immune suppression, genomic instability, metastasis and angiogenesis via AGE-RAGE signalling cascade. The gene discussed is AGER; the disease is cancer.