Role of RAGE in subsidising mitochondrial bio-energetics (ATP) and metastatic dissemination EMT are to be underlined, considering the AGEs-RAGE interlink and the upregulated glycolytic rate in cancer cells (shown in Figure 1), and hence lactate turnover, the main fuel for metastatic cancers [31, 34]. Here, AGER is linked to metastatic malignant neoplasm.