The augmented presence of RAGE in the invasive front [79] and AGE levels in the advanced disease stage [26], along with the concurrent rise in different cytokines, confirm the concomitance of AGEs and RAGE with the metastatic and malignant nature of cancers, while simultaneously establishing the connection between metabolic switch of cancers to inflammation via AGEs-RAGE conjunction in cancers. The gene discussed is AGER; the disease is cancer.