Pan et al. [45], established the concomitance of AGEs and breast cancer metastasis via instigation of RAGE/Toll-like receptor 4 (TLR4)/myeloid differentiation primary response factor 88 (MyD88) signalling with up-regulated MMP9 expression and nuclear translocation of NF-κB, reduced IκB expression [45]. The gene discussed is AGER; the disease is breast cancer.