Such nanoparticles surface-functionalized with RAGE were shown to exhibit enhanced bioavailability and augmented target specificity to cancer (TNBC/MDA-MB-231) cells, with elevated accretion in acidic tumour micro-milieu and increased (61.8%) cytotoxic impact on TNBC/MDA-MB-231 cells [114]. The gene discussed is AGER; the disease is cancer.