Recent studies have revealed the alteration in composition of gut microbiota and induction of insulin resistance, along with subsequent shift in colonocyte structure, rise in colon permeability, reduction in expression of tight junction proteins, ultimately leading to intestinal epithelial barrier dysfunction, with resultant augmentation of RAGE NF-κB signalling upon exposure to dietary AGEs [94–96]. The gene discussed is NFKB1; the disease is Insulin resistance.