AGER and neoplasm: In this review, the AGE-RAGE pathway driven facilitation of intricate oncogenic cues in tumour-micro environment, budding from the metabolic (glycolytic) reliance of tumour cells triggering superfluity of AGEs, branching into metastatic emergence of malignancies via RAGE-reliant and -independent mechanisms, with alterations in epigenome, gut microbiome and metabolome.