AGE-RAGE expression has been directly correlated with cancer malignancy, with higher propensity for metastasis and poor survival in cancer-afflicted patients with diabetes, potentially due to the underlying role of pre-existing AGEs in promotion of cell migration, ERK phosphorylation, RAGE, MMP2 and 9 expression, which were indeed curbed by the use of RAGE antibodies and RAGE interfering RNA (RNAi). This evidence concerns the gene AGER and diabetes mellitus.