Interaction between SjE16.7 (calcium binding protein) secreted from the eggs of Schistosoma japonicum and RAGE in host cells, with resultant instigation of NF-κB signalling pathway, ROS generation and pro-inflammatory cytokine (IL-6 and TNF-α) secretion, stimulated colorectal cancer development in mouse model. This evidence concerns the gene NFKB1 and colorectal cancer.