Apoptotic evasion by RAGE is evidently invoked via p53 attenuation, since RAGE depletion augments caspase-3 activity and facilitates apoptosis, while p53 antagonist suppresses caspase-3 stimulation and cell death in the same RAGE depleted cells, ensuing chemotherapy in pancreatic cancer cells in vitro [64]. This evidence concerns the gene TP53 and familial pancreatic carcinoma.