Importantly, we found that our mouse model of breast cancer demonstrated signs of cardiac remodeling at the molecular level as evidenced by a significant reduction in Myh6 gene expression19 (Figure 1D); a slight but not significant increase in heart weight/tibia length (TL); and significant increases in LV end-systolic volume/TL, LV internal diameter systole/TL, and LV internal diameter diastole/TL compared with control mice (Figures 1F, 1G, 1I, and 1J). The gene discussed is MYH6; the disease is breast cancer.