APOL1 and HIV-associated nephropathy: In particular, APOL1-G2 does not appear to increase the risk of heterozygous individuals to develop ESRD) or HIVAN, or the age in which the kidney diseases appeared but, unlike the G1 allele, is present in all documented individuals with interferon-associated APOL1 nephropathy (Friedman and Pollak, 2020; Nichols et al., 2015).