According to the heatmap, there were 15 CpG sites in SAMD13 and we found that average methylation of all CpG sitesof SAMD13 (Overall; Aggregation, p = 2.4e-05), including N_Shore (Aggregation, p = 0.00048), S_Shore(Aggregation, p = 0.058), S_Shelf (Aggregation, p = 0.039), and Open_Sea (Aggregation, p = 6.3e-14) was significantly lower in tumor tissues than in the normal counterpart (Fig. 4C). This evidence concerns the gene SAMD13 and neoplasm.