In patients with HCC, high levels of neutrophil, macrophage (tumor-derived macrophage or macrophage M2), and MDSC are reported to be associated with poor survival [33–35], it is hypothesized that SAMD13 may play an important role on the TME in HCC and further study of the immune microenvironment and HCC feature should be addressed. Here, SAMD13 is linked to neoplasm.