SAMD13 and hepatocellular carcinoma: In patients with HCC, high levels of neutrophil, macrophage (tumor-derived macrophage or macrophage M2), and MDSC are reported to be associated with poor survival [33–35], it is hypothesized that SAMD13 may play an important role on the TME in HCC and further study of the immune microenvironment and HCC feature should be addressed.